The World Health Organization (WHO) expressed serious concerns after reporting over 306,000 measles cases worldwide last year, representing a 79% increase from the previous year.
"We in the measles world are extremely concerned," said Natasha Crowcroft, a WHO technical adviser on measles and rubella.
She stressed though that measles cases are typically dramatically under-reported and that the real number was surely far higher.
To get more accurate figures, the U.N. health agency models the numbers each year, with its latest estimate indicating that there were 9.2 million cases and 136,216 measles deaths in 2022.
Such modeling has not yet been done for last year, but Crowcroft pointed out that 2022 had already seen a 43% jump in deaths from the year before.
Given the ballooning case numbers, "we would anticipate an increase in deaths in 2023 as well," she told journalists in Geneva, via video-link from Cairo.
"This year is going to be very challenging."
She warned that more than half of all countries globally are currently believed to be at high risk of measles outbreaks by the end of the year.
And some 142 million children are estimated to be susceptible to falling ill.
Measles is a highly contagious disease caused by a virus that attacks mainly children. The most serious complications include blindness, brain swelling, diarrhea and severe respiratory infections.
A major cause of the swelling numbers is the "backsliding immunization coverage," Crowcroft said.
At least 95% of children must be fully vaccinated against the disease in a locality to prevent outbreaks, but global vaccination rates have slipped to 83%.
There is a great deal of inequity in the distribution of cases, and even more so when it comes to deaths.
Crowcroft pointed out that 92% of all children who die from measles live among less than a quarter of the global population, mainly in very low-income countries.