Heavy downpours added to the ongoing humanitarian tragedy of displaced Palestinian people who have been left without homes and nowhere safe to flee under heavy bombardment by Israel.
The start of the rainy season and the possibility of flooding increased fears that the densely populated enclave's sewage system would be overwhelmed and disease would spread.
At a U.N. shelter in Khan Younis in southern Gaza, the rain brought dismay for displaced people who woke to find the clothes they put out to dry the night had been drenched by rain.
"We were in a house built of concrete and now we are in a tent," said Fayeza Srour, who sought safety in the south after Israel began its relentless attacks.
"The nylon tarps, the tent and the wood will not resist any flooding... People sleeping on the floor, what will they do? Where will they go?"
Winters can be wet and cold in Gaza, and the enclave is sometimes hit by flooding.
Another displaced Gazan, Karim Mreish, said people at the shelter were praying for the rain to stop.
"Those children, those women, those elderly pray to God that it doesn't rain," he said. "If it does it will be very difficult and words will fail to describe our suffering."
The World Health Organization (WHO) said last week that Gaza faced an increased risk of disease spreading because Israeli air bombardments had disrupted the health system, limited access to clean water and caused people to crowd in shelters.
It voiced concern on Tuesday about the prospect of rain causing flooding and overwhelming already meager and damaged sewage facilities.
"We've already got outbreaks of diarrhoeal diseases," WHO spokesperson Margaret Harris said in Geneva.
She said there were more than 30,000 cases of diarrhea in a period when WHO would normally expect 2,000 cases.
"We've got so much infrastructural damage. We've got a lack of clean water. We've got people very, very crowded together. This is another reason why we are begging for a ceasefire to happen now," she said.
Ahmed Bayram, a spokesperson for the Norwegian Refugee Council, said the start of the rainy season could mark "the most difficult week in Gaza since the (military) escalation began."
"Heavy rains will mean more impeded movement for people and rescue teams," he said. "It will make it harder to save people stuck under the rubble, or to bury the dead, all of this amid ceaseless bombardment and a fuel shortage catastrophe."
Facing the daunting scale of the humanitarian needs of Gaza's 2.3 million people, aid organizations have been unable to plan for the challenges posed by rain and flooding.
Juliette Touma, Director of Communications at the U.N. Palestinian Refugee Agency (UNRWA), said the organization was focused on meeting the population's needs "here and now."
"We're barely able to make it from one hour to the next ourselves because the situation on the ground is so, so, so desperate," she said.
Touma said just a small amount of rain could cause the streets of Gaza to flood, given the sewage system's inability to absorb water.
"This is on a normal day. This is not when half of Gaza, if not more, is in rubble," she said.
The International Committee of the Red Cross (ICRC) said it had also been unable to plan far beyond Gazans' daily needs.
"The situation is so volatile and complicated as a result of the hostilities that we have focused really squarely on the humanitarian consequences as they shift from one day to the next," said William Schomburg, head of the ICRC delegation in Gaza.
The rain brought relief for some displaced Palestinians in the central Gaza Strip town of Deir Al-Balah who had not been able to drink clean and fresh water in the past weeks. Some placed plastic buckets outside their tents to gather rainwater to drink.
"We have been drinking salty water for 30 days. There has been no fresh water. I have just collected this from the rainwater," said Um Mohammad Shahin.