Jake Paul commented that leading boxers have become excessively preoccupied with preserving their unblemished records and should demonstrate greater openness to engaging in high-profile bouts.
Britain's Tyson Fury and Ukraine's Oleksandr Usyk agreed late last year to a heavyweight unification title fight, but the talks broke down in March.
Former world heavyweight champion Anthony Joshua invited Fury to think again about a future fight, though nothing has been finalized.
"It's annoying; I think in boxing, fighters are not willing to risk their undefeated record and put it all on the line," YouTuber-turned-boxer Paul told Sky Sports on Sunday at Formula One's Miami Grand Prix.
"Their legacy and being undefeated is more important to them because Floyd Mayweather set that example for the sport, so if you lose, you're 'swept under the rug' in boxing."
Paul applauded Ryan Garcia for agreeing to face the unbeaten Gervonta Davis last month in the non-title catchweight fight, even though he suffered his first career defeat.
"Even though he lost, he did what many other fighters weren't doing and made big fights happen," Paul added. Having lost to Tommy Fury in their fight in Saudi Arabia in February, Paul said he is confident of facing the British reality TV star in a rematch.
"It's going to happen; it's going to happen for sure," Paul said. "Tommy is down, and I'm excited about that."