This will be a triumph for Quique Setien to savor, as Villarreal stunned La Liga defending champions Real Madrid with a 2-1 victory on Saturday, reestablishing the reputation of a coach who had been absent from the footballing world for two years following his ill fated tenure at Barcelona.

The pulsating Spanish league match at Villarreal's remodeled Estadio de la Ceramica could have ended with more goals, especially for the all-yellow hosts.

Gerard Moreno, who missed the World Cup for Spain due to injury, led Villarreal with an assist and a goal against the Spanish and European champions.

Yeremy Pino put Villarreal deservedly ahead in the 47th minute from a pass by Moreno after Ferland Mendy lost possession with an errant pass. However, a handball by Villarreal's Juan Foyth allowed Karim Benzema to level from the penalty spot in the 60th momentarily.

But another handball, this time by Madrid defender David Alaba on a pass by Foyth, sent Moreno to take the winner for Villarreal in the 63rd.

Villarreal, which held Madrid to five consecutive draws at its stadium, took the initiative and forced Madrid's defenders into sloppy passing. Francis Coquelin hit the post in the fifth with a superb shot with the back of his heel while on the turn, slicing the ball from a tight angle past Thibaut Courtois. That pressure led to the breakthrough by Pino just after halftime.

"No doubt, today we played an extraordinary match against an extraordinary team," Setien said. "We were better in many aspects, kept the action in their half of the field, and created our scoring chances. In addition, we increased our pressure because we know that if you give them room, they can cause you problems."

The 40-year-old Pepe Reina started in Villarreal's goal, hours after the club announced it transferred Argentine Geronimo Rulli to Ajax. Reina blocked a shot by Vinicius Junior in Madrid's best chance late in the first half.

Setien was considered one of Spain's brightest coaching minds before he joined Barcelona in January 2020 for his first job with an elite club. However, he lasted just eight months and was let go following Barcelona's 8-2 loss to Bayern Munich, its worst loss in recent memory.

The 64-year-old manager returned to coaching only in October when he accepted the challenge of replacing Unai Emery, who left for Aston Villa following his successful run at Villarreal that included a Europa League title and the Champions League semifinals.

Setien has had a rough start at Villarreal, drawing in his debut and losing the next three matches. But the team started to win and played even better following the World Cup break. It beat Valencia in a regional derby before taking down Madrid to climb into fifth place in the standings.

Setien, known for his attacking style, tweaked a successful scheme under Emery and found another way to win. Pino has moved from the right to the left side of the attack, allowing Samuel Chukwueze to play on the right and provide speed on both flanks. Alex Baena, enjoying a breakout season, shifted into an interior role, while Dani Parejo has moved further back in the midfield to act as its primary playmaker.

"I always believed," Setien said. "Our start was not the best one. There was a shock in the club with a new coach who wanted to change things even though the team was playing well. But I am a man of convictions and knew that this would work out."

Madrid's loss allowed Barcelona to regain the sole lead in the competition on Sunday when it visits Atletico Madrid.

Madrid will pause league plays to compete in the Spanish Super Cup in Saudi Arabia along with Barcelona, Real Betis, and Valencia. Once back in Spain, Madrid will face another trip to Villarreal in the Copa del Rey quarterfinals.

Madrid coach Carlo Ancelotti called on his defense to play better.

"We didn't defend like we wanted to; we left too many spaces between our lines," Ancelotti said. "We have to interpret the moments of the game better. Now we have to focus on the Super Cup."

Madrid's starting 11 included no Spanish players. According to Opta statistics, this was the first time Madrid did not have a Spaniard on the field at kickoff in a Spanish league game in this century. Other local media said this was the first time in the club's history.