Following a left knee injury sustained during a World Cup qualifier against Uruguay, Neymar will undergo surgery for a ruptured anterior cruciate ligament and meniscus, sidelining the forward for several months, according to Brazil's Football Association.
The 31-year-old went down after tussling for the ball with Uruguay's Nicolas de la Cruz in the 44th minute of Brazil's 2-0 defeat on Tuesday, holding his left leg in pain and calling for medical attention as his team mates looked on anxiously.
Neymar, who signed for Saudi Arabian side Al-Hilal in August, left the pitch in tears on a stretcher after receiving treatment for several minutes, and an MRI scan on Wednesday confirmed the injuries.
"The striker will undergo surgery, on a date yet to be set, to correct the injuries," Brazil's Football Confederation (CBF) said in a statement on Wednesday.
"The medical department of the Brazilian national team ... and Al-Hilal are in constant contact and are aligned in the athlete's recovery."
Neymar said he was frustrated to be sidelined with yet another injury so soon after recovering from an ankle operation.
Earlier this year, he underwent right ankle surgery that required months of recovery before he left Paris Saint Germain to sign a two-year deal with Al-Hilal, where he had played only five games this season.
"It's a very sad time, the worst," he wrote on Instagram. "I know I'm strong, but this time I'm going to need my family and friends even more.
"It's not easy to go through injury and surgery, imagine going through it all again after four months of recovery."
Neymar's career has been plagued with injuries. He spent three lengthy spells on the sidelines with his former club Paris Saint-Germain after sustaining right foot injuries.
At the 2014 World Cup, he suffered a back injury in the quarterfinal victory over Colombia, ruling him out of the 7-1 semifinal defeat by Germany.
In 2018, injuries again hampered his dream of winning the World Cup. Early that year, Neymar suffered a sprained right ankle that affected the fifth metatarsal in his foot.
He missed 16 games for PSG at the end of the 2017-18 domestic season and was never fully fit as he played through the pain for Brazil in Russia until they were knocked out by Belgium in the quarterfinals.
The forward suffered similar injuries in 2019, 2021 and at last year's Qatar World Cup.
The latest injury will be a bitter blow to Al-Hilal, who paid a reported 90 million euros ($95 million) for the forward.
The club is unbeaten in the Saudi Pro League and leads by one point, while they are also top of their AFC Champions League group after two games.