Scientists have found a hidden chamber in Egypt's Great Pyramid of Giza, the first such discovery in the structure since the 19th century and one likely to spark a new surge of interest in the pharaohs.

In an article published in the journal Nature on Thursday, an international team said the 30-meter (yard) void deep within the pyramid is situated above the structure's Grand Gallery, and has a similar cross-section. The purpose of the chamber is unclear, and it's not yet known whether it was built with a function in mind.

"It is big," said co-discoverer Mehdi Tayoubi of the ScanPyramids project, which has been exploring Khufu's pyramid since October 2015 with non-invasive technology using subatomic particle scans.

"It's the size of a 200-seater airplane, in the heart of the pyramid," Tayoubi told AFP of the discovery, published in science journal Nature.

The scientists made the discovery using cosmic-ray imaging, recording the behavior of subatomic particles called muons that penetrate the rock similar to X-rays, only much deeper. Their paper was peer-reviewed before appearing in Nature, an international, interdisciplinary journal of science.

The pyramid is also known as Khufu's Pyramid for its builder, a 4th Dynasty pharaoh who reigned from 2509 to 2483 B.C. Visitors to the pyramid, on the outskirts of Cairo, can walk, hunched over, up a long tunnel to reach the Grand Gallery. The newly discovered chamber does not appear to be connected to any known internal passages.

Scientists involved in the scanning called the find a "breakthrough" that highlighted the usefulness of modern particle physics in archaeology.

The void, said co-author Kunihiro Morishima from the Nagoya University in Japan, "was not known by anyone until now, from when the pyramid was built 4,500 years ago".

"The big void is completely closed," he added, which means anything inside it would not have been "touched by anyone after the pyramid (was) built".

The pharaohs of ancient Egypt built these monumental tombs for themselves, complete with sarcophagus to hold their embalmed mummies, and stocked with everything they could require for the afterlife -- food, clothing and jewellery.

The pyramids at Giza, the last surviving wonder of the ancient world, have captivated visitors since they were built as royal burial chambers 2,500 years ago. Experts are still divided over how they were constructed, so even relatively minor discoveries generate great interest.

Late last year, for example, thermal scanning identified a major anomaly in the Great Pyramid — three adjacent stones at its base which registered higher temperatures than others, stoking imaginations worldwide.

Speculation that King Tutankhamun's tomb contains additional also antechambers stoked interest in recent years, before scans by ground-penetrating radar and other tools came up empty, raising doubts about the claim.

The muon scan is accomplished by planting special plates inside and around the pyramid to collect data on the particles, which rain down from the earth's atmosphere. They pass through empty spaces but can be absorbed or deflected by harder surfaces, allowing scientists to study their trajectories and discern what is stone and what is not. Several plates were used to triangulate the void discovered in the Great Pyramid.

Tayoubi said the team plans to work with others to come up with hypotheses about the area.

"The good news is that the void is there, and it's very big," he said.