Roma could be left ruing a poor second-half performance after allowing Shakhtar Donetsk to come from a goal down to win 2-1 in the first leg of their Champions League last-16 meeting Wednesday.

Turkey international Cengiz Ünder continued his fine run of form by giving Roma the lead shortly before halftime but Facundo Ferreyra leveled for Shakhtar shortly after the break and Fred showed why some of Europe's top clubs are reportedly after him with a perfect free kick in the 71st minute.

"I seem to have seen two different Roma teams today on the pitch. After conceding the first goal I should have substituted most of them," Roma coach Eusebio Di Francesco said. "In the first half the team played to attack and then they played to manage I don't know what. For that reason I'm angry.

"I can't think we were presumptuous when winning, it's not as if Roma gets to the final every year. But in the second half we were too sloppy in our passing, something which we were perfect in in the first half."

Roma's players were similarly disappointed, with captain Daniele De Rossi admitting they "stopped playing" after Shakhtar's equalizer and the result "leaves us with a bitter taste."

Midfielder Diego Perotti couldn't believe his team's transformation after the break.

"What happened between the first and second half? I don't know, I'm asking myself that too," Perotti said. "Based on our first-half performance we deserved to win, and I'm very upset about the wretched second half we played. It's all our fault, there are no excuses, we're responsible."

Roma dominated the first half but it was the Italian club's Alisson who was the busier of the two goalkeepers, especially as the match wore on.

"We didn't actually start the game too badly, and even created a good chance, but didn't have a player to poke the ball in," said Shakhtar coach Paulo Fonseca. "Later there was a problem with our positioning. Roma were aggressive while our lines were stretched. We sorted this after the break and that helped us win.

"The team performed well in the second half. It wasn't easy to keep up that pace after a long winter break. The only reason we didn't win by a bigger margin was a brilliant display from the Roma keeper."

Manchester United goalkeeper David de Gea was also kept busy as he helped his side to a 0-0 draw in the night's other match.

Shakhtar is playing its home matches in Kharkiv, as the stadium in Donetsk was damaged by the conflict in Ukraine.

There were early chances for both sides with Roma going the closest but Edin Dzeko saw his attempt parried from close range by Andriy Pyatov, who then did well to kick away the ball.

Roma started to take control and took a deserved lead four minutes from halftime. Dzeko put in a perfectly-weighted pass to Ünder, whose finish bounced off Pyatov and into the far side of the net.

It was the 20-year-old Turkish winger's fifth goal in four matches and the perfect way to mark his Champions League debut.

Shakhtar defender Serhiy Kryvstov was then taken off on a stretcher before the break with a badly sprained ankle and had to be replaced by Ivan Ordets.

However, the home side leveled six minutes after the interval thanks to a mistake from Alessandro Florenzi, who had started the match despite a flu bug.

The Roma midfielder missed Yaroslav Rakitskiy's through ball, allowing Ferreyra to latch onto it and run around Manolas to fire past Alisson.

Alisson pulled off a number of good stops, including a brilliant save to fingertip Taison's effort away, but could do nothing to prevent Fred's 20-yard free kick from going into the top right corner.

Shakhtar almost extended its lead in stoppage time but Bruno Peres did well to clear Ferreyra's effort off the line.

It was another impressive result for Shakhtar, which beat Manchester City and Napoli in Ukraine in the group stages of this season's competition.

In the night's other game, David de Gea deflected the attention away from Paul Pogba with another spectacular display of goalkeeping as Manchester United came away from their Champions League last 16, first leg against Sevilla in Spain with a 0-0 draw on Wednesday.

De Gea made two breathtaking saves to deny Steven N'Zonzi and Luis Muriel at the end of the first half at the Ramon Sanchez Pizjuan, denying Sevilla a lead to take to England for next month's return.

Sevilla were the more likely side, with United offering little going forward despite the presence of Alexis Sanchez, Romelu Lukaku and Juan Mata in their attack.

The scoreless result left the tie open heading into next month's second leg in Manchester, when Sevilla will be trying to make it to the quarterfinals for the first time and United will look to return to the last eight after three seasons.