No Hollywood star seems as intrinsically tied to Venice as George Clooney.

Twenty-six years ago, he attended his first Venice Film Festival with the instant classic "Out of Sight"; 19 years ago, it’s where he debuted his sophomore film, "Good Night, and Good Luck," which earned him his first best director nomination; and 10 years ago, it’s where he exchanged vows with then Amal Alamuddin, at the Aman Venice, a five-star hotel perched alongside the Grand Canal.

Venice is a city that he, like many, thinks is one of the most beautiful in the world. Unlike most people, he also owns a 15-bedroom villa a few hours away on Lake Como that famously co-starred in "Ocean’s Twelve."

Though he’s never far from Venice or the city’s namesake film festival, it might be a surprise that Clooney hasn’t had a film debut there in seven years. But that clock resets next week as he returns with "Wolfs," the Jon Watts-directed heist thriller that reunites him with Brad Pitt.

It won’t be the first time Clooney and Pitt have graced the festival’s red carpet together. In anticipation of his big return, here are some of Clooney’s most memorable Venice moments.

As legend has it, Clooney's long-term love affair with Venice may have begun with the festival's premiere of Steven Soderbergh's Elmore Leonard adaptation "Out of Sight." Then 37 and doing press alongside Jennifer Lopez, the actor would also make another big jump soon: Leaving "ER" that February.

This Coen brothers joint, co-starring Catherine Zeta-Jones, premiered out of competition at the 60th Venice Film Festival, alongside titles like "Matchstick Men," "Once Upon a Time in Mexico" and "The Dreamers." Clooney's nearby Italian residence was already as famous as him and a stakeout spot for amateur and professional paparazzi.

In a profile that fall, while shooting "Ocean's Twelve," Vanity Fair writer Ned Zeman observed: "That an affable, self-effacing Kentucky-born Hollywood actor is fast becoming the most popular public figure in Italy says a little about Italy and a lot about Clooney, who isn’t Italian, doesn’t speak Italian and lives here only in summertime."

Clooney's acclaimed black-and-white dramatization of journalist Edward R. Murrow's clash with Joseph McCarthy began its successful run in competition at the 62nd Venice Film Festival. Though it lost the Golden Lion to Ang Lee's "Brokeback Mountain," it picked up six Oscar nominations, including for Clooney's directing. Next year, he'll also make his Broadway debut in an adaptation.

He also inspired a cocktail still served at the ritzy Belmond Hotel Cipriani on Giudecca during the trip. The two would later name a Prosecco, passionfruit and elderflower cocktail La Nina after Clooney's mother, which was served at his wedding.

Tony Gilroy's "Michael Clayton," which nabbed Clooney an Oscar nomination for his turn as the titular law firm fixer, played in competition at Venice. The top prize went again to an Ang Lee film: "Lust, Caution," which also beat out the likes of "I'm Not There," "Atonement," and "The Assassination of Jesse James by the Coward Robert Ford."

This Coen brothers comedy featuring Clooney and Pitt opted to debut out of competition in the opening night slot. He said it completed his "trilogy of idiots" that he'd played for the Coens, including "Intolerable Cruelty" and "O Brother, Where Art Thou?" "Looking at the parts we are playing, I’m very concerned about what you think of us," Clooney said at the press conference. Pitt, who'd won the festival's acting prize the year prior, added: "Like George ... I’m not sure if I should be flattered or insulted."

Another opening night, out-of-competition slot debut for this Clooney-directed campaign thriller starring Ryan Gosling and Philip Seymour Hoffman. As usual, Clooney was peppered with political questions, and he observed that "it's a very difficult time to govern."

Alfonso Cuarón's "Gravity" opened the 70th edition of the Venice Film Festival before winning seven Oscars. Clooney attended the premiere alongside Sandra Bullock and was self-deprecating about his role: "There were only two parts and Sandy had the other one, so I felt like this was the only one I could get away with."

The canals were packed with paparazzi for the nuptials of one of Hollywood's favorite bachelors. On Sept. 27, Clooney, then 53, and Alamuddin, then 36, exchanged vows in front of 100 of their closest friends and family, including Bono and Matt Damon, at the luxury hotel Aman Grand Canal, originally a grand palazzo built in 1550. She wore a custom Oscar de la Renta dress with French lace, pearls and diamanté accents. He wore a black wool/cashmere Giorgio Armani tuxedo.

Clooney returned to the festival with another of his directing projects, "Suburbicon," a dark comedic satire about a seemingly idyllic 1950s community with Damon and Julianne Moore. This festival was especially notable for being the Clooneys' first public appearance since the birth of their twins, Alexander and Ella, a few months prior.

This time, George was the plus one to Amal, who received an award from the Diane von Furstenberg and The Diller-von Furstenberg Family Foundation for her work as a human rights lawyer. The power couple gave last year's festival some much-needed star power amid the actor's strike with an appearance at the adjacent DVF Awards. "I am here in Venice with my husband; he is a rising star," she said that night. "I just wanted to say, you, my love, like this city, take my breath away."